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Furthermore, CBP and p300 activate CCR4-related factor 1 through acetylation, a process that promotes mRNA degradation [51]

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[DOI] [PubMed] [Google Scholar] [77].Wu HY, Ward FJ, Staines NA

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By enhancing levels of dopamine, norepinephrine, and serotonin, tesofensine appears to suppress appetite and elevate mood, which may help mitigate some of the underlying drivers of stimulant misuse
