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In parallel, hepatocyte-directed PPAR gene therapy has been shown to enhance systemic -hydroxybutyrate availability, providing a neuroprotective energy substrate during cerebral metabolic crisis [128, 284, 285]

Data Availability Statement Some or all data, models, or code that support the findings of this study are available from the corresponding author upon reasonable request.

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Additionally, in a study of chronic fatigue syndrome, eight people dropped out because of overstimulation and insomnia [42]

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: implications for treatment resistance

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