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These findings underscore the important role of the microbiota-gut-brain axis in the pathogenesis of PD

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de Matos OG, Amaral SS, Pereira da Silva PE, Perez DA, Alvarenga DM, Ferreira AV, et al
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doi:10.1042/bj2770273

The primary enzyme responsible for breaking down histamine in the central nervous system is histamine N-methyltransferase (HNMT)