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In The metabolic basis of inherited disease

Appetite Suppression Studies: Potently reduces food intake in preclinical models

Standard GLP-1 contraindications still apply Compounded semaglutide has safety risks and contraindications to consider: Semaglutide is not indicated for patients with a personal or family history of thyroid tumors, particularly medullary thyroid carcinoma (MTC) and neuroendocrine tumors such as MEN 2 (multiple endocrine neoplasia) type 2 syndrome

this is mechanistically rich but not a substitute for clinical outcome data

Researchers should record baseline metrics, use vehicle controls, and apply blinded scoring where possible

doi: 10.1111/anu.12037