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This results in an increase in a number of major microbial-derived uremic toxins (Table 1), including indoxyl sulphate (IS), indole-3-acetic acid (IAA), p-cresyl sulphate (PCS) and trimethylamine-N-oxide (TMAO) [15, 70, 71]
The good news: its temporary , and hair usually grows back on its own without treatment
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Interestingly, rat pituitary adenoma GH3 cells lacking functional AIP, generated with CRISPR/Cas9 editing, showed a strong increase in GH mRNA levels and secretion, and a slight increase in cell proliferation compared to the parental GH3 cells (56)
Referenced in experimental models examining cellular communication and tissue-related pathways
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