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[DOI] [PubMed] [Google Scholar] 78.Higuchi T., Abe M., Yamazaki T., Okawa E., Ando H., Hotta S., Oikawa O., Kikuchi F., Okada K., Soma M

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The detoxification period lasted for three weeks, while the researchers evaluated the pain levels and withdrawal symptoms

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It does this by naturally improving the stimulation of the reward system, which reduces the need for stimulation by nicotine or by others addictive substances (85)

In addition to its role in cellular defense, the Nrf2 pathway has been implicated in numerous physiological and pathophysiological processes, including aging, neurodegeneration, cancer, and metabolic disorders [77]