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Lin28B derived from BC exosomes stimulates lung fibroblasts, neutrophils, and macrophages to release CXCLs, IL-6, and IL-10, respectively, resulting in neutrophil recruitment and N2 transformation, creating an immunosuppressive microenvironment conducive to tumor metastasis [131]

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Research indicates that patients receiving VK antagonists and ASMs may face an increased risk of bleeding complications, particularly when VK levels are not adequately maintained [13]

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Carboplatin demonstrates high clearance from the brain tissues, therefore, temporary BBB disruption during the treatment leads to higher efficiency of treatment [86, 87]