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DUX4 protein also interacts with the transcriptional coactivator p300 and utilizes its acetyltransferase activity to induce expression of many of its target genes [34, 75, 164]

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Attractively, ascorbic acid (100 mg/kg-1000 mg/kg, intraperitoneal injection, as bioequivalent of an intravenous drip dose of 0.48 g4.8 g ascorbic acid per day in humans) produces rapid-acting antidepressant effects via triggering DNA demethylation catalyzed by ten-eleven translocation dioxygenases

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doi: 10.1002/jat.3303