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What You Should Know Your body cant make ergothioneine and must get it entirely through diet, mostly from mushrooms A dedicated transporter protein specifically moves ergothioneine to tissues most vulnerable to age-related damage Recent studies show it boosts NAD+ levels, improves exercise endurance, and protects cognitive function Studies link higher blood levels to 21% lower cardiovascular mortality and 50% reduced cognitive decline risk What is Ergothioneine

Biochemistry (Mosc) 88:515525 [DOI] [PubMed] [Google Scholar] 81.Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S et al (2012) Mitochondrial dysfunction associated with increased oxidative stress and -synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

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Immunoblot analysis using specific antibodies for each NS protein revealed that the DDM-supplemented reaction produced mature forms of NS2B, NS4A, NS4B, and NS5 at their expected molecular weights, alongside the full-length and partially cleaved polyproteins (Fig