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The limited human evidence is the elephant in the room

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Vitamin B12 can cause dermatitis, acne, and other skin-related conditions when taken in excess, according to a review in the American Journal of Clinical Dermatology

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Adjusting the dose for each patients needs is vital for safe and effective treatment

According to Cant et al., Cell Metabolism , increased NAD stimulates PGC-1 activity, driving mitochondrial biogenesis and substrate flexibility