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It is also characterized by iron overload and downregulated expression of anti-oxidant proteins, including glutathione peroxidases (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase 4 (GPX4)

Eur J Pharmacol 367(2-3):157163 Pugliese AM, Coppi E, Volpini R, Cristalli G, Corradetti R, Jeong LS, Jacobson KA, Pedata F (2007) Role of adenosine A3 receptors on CA1 hippocampal neurotransmission during oxygenglucose deprivation episodes of different duration

A primary consideration is the tradeoff broad-spectrum senolytic effect and the negative effects on normal proliferating cells, due to the lack of clearly defined boundaries between senescent and cells undergoing milder, but non-senescence-inducing stresses, or even non-senescent cells that express markers of senescence

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Also, Vitamin B12 supplementation works best when paired with sun exposure or UV therapy

The mechanical properties of the extracellular matrix itself, including its stiffness and topographical cues, as discussed above, also exert profound guidance over fibroblast movement, directing them towards areas of injury and remodeling