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It can directly interact as a signalling molecule influencing opening of K+ channels and regulation of Ca2+ channels

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The literature search supports the conclusion that metformin is neuroprotective against DM-induced neuronal cell degeneration in both peripheral and central nervous systems, and this effect is likely mediated via modulation of oxidative stress, inflammation, and cell death pathways.

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As one of the earliest and most extensively studied GHS compounds, GHRP-6 has played a foundational role in advancing scientific understanding of non-GHRH-mediated growth hormone signalling pathways
