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ROS accumulation disrupts insulin signaling by inhibiting insulin receptor substrate (IRS) proteins, which subsequently reduces the translocation of glucose transporter type 4 (GLUT4) to the plasma membrane and lowers glucose uptake in peripheral tissues such as muscle and adipose tissue

10.1016/j.biopsych.2018.12.020 128

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

[DOI] [PubMed] [Google Scholar] 134.Cramer K.S., Leamey C.A., Sur M

[DOI] [PMC free article] [PubMed] [Google Scholar] 172.Kim E.C., Meng H., Jun A.S

Weber authored a review of the research, published early this year, noting the lack of evidence supporting their clinical use