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301,302 Key targets of the STAT pathway and their related regulatory mechanisms are shown in Fig

It is usually worsened by exposure to the sun

2.3 Failure of antioxidant system Nuclear factor erythroid 2-related factor 2 (NRF2) orchestrates cellular antioxidant defense by directly regulating glutathione (GSH) biosynthesis and GPX4 expression through transcriptional control of Glutamate-Cysteine Ligase Catalytic Subunit(GCLC)/ Glutamate-Cysteine Ligase Modifier Subunit(GCLM) and GPX4 (Fan et al., 2024)

Although Alox5 was differentially expressed in the RNA-seq dataset, Slc7a11, Gpx4, and Nrf2 did not meet significance thresholds, likely reflecting differences in assay sensitivity or the limited RNA-seq sample size

doi: 10.18632/oncotarget.20798

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