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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates

In sum, silibinin stands out for its ability to orchestrate multiple anti-cancer pathways, spanning immunity, autophagy, and epigenetic control, while also optimizing standard therapies and alleviating their toxicities

10.1038/s41556-018-0118-z 91 Garcia-NavasR.MunderM.MollinedoF

Neuronal redox-imbalance in Rett syndrome affects mitochondria as well as cytosol, and is accompanied by intensified mitochondrial O 2 consumption and ROS release

10.1042/BJ20061119 21

Inflammation, steatosis, ballooning, and fibrosis are the features of non-alcoholic fatty liver disease (NAFLD), and the associated critical bona fide genes such as MCP-1, TNF, TNFR1, TGF1, Col1, SMA, Timp1, and Hp were significantly enriched in the livers of mice fed an HFD