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Additionally, thioredoxin-1, a core component of the thioredoxin system, also contributes to these protective effects by maintaining cellular redox balance (237, 238)

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The effects of hyaluronan on proliferation of these fibroblasts was found to involve differential effects on membrane polarization, where high molecular weight hyaluronan results in depolarization and low molecular weight hyaluronan causes membrane hyperpolarization and inhibits proliferation