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10.3382/japr.2007-00107 J

The association of disordered amino acid metabolism with hepatic steatosis in cross-species animal models including geese, ducks, and rats further supports its role in human fatty liver [149,150,151]

All studies were approved by and performed according to the ethical guidelines by the Chungbuk National University Animal Care Committee (CBNU-523-13-01)

Additionally, after IOPs treatment, the protein expression of PI3K-p85, p-Akt (ser473), and glucose transporter protein 4 (GLUT4) was upregulated, suggesting that the anti-hyperglycemic mechanism of IOPs may involve the activation of PI3K and Akt phosphorylation, and GLUT4 transport in diabetic mice (Wang et al., 2017)

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This interaction signals the pituitary gland to release growth hormone in a controlled manner, leading to pulsatile GH release