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Downstream effectors: mTOR, FOXO, and the atrophyhypertrophy balance Following the PI3K/Akt activation described above, several effectors determine the biological readout

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Even microscopically, it may be impossible to differentiate hepatic nodular hyperplasia from hepatocellular adenomas, and a large sample (wedge rather than needle biopsy) may be required to confirm hyperplasia from well-differentiated HCCs.75, 76, 77 Routine abdominal radiographs are generally unremarkable and ultrasonographic features are inconsistent because of the varied hepatocellular morphologic characteristics and size of the nodules

End-binding proteins Proteins that associate with the plus ends of microtubules and regulate their dynamics

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( 10.1186/s13195-017-0283-5) [DOI] [PMC free article] [PubMed] [Google Scholar] 165.Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H