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PMID: 10037025

Hydroxocobalamin is preferred because it has a longer half-life and is retained in the body more effectively than cyanocobalamin (which is mainly available as oral supplements in the UK)

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It addresses the coupling of systemic nutritional states (wellfed versus fasting), hepatic filtering, and a tumor-specific firstpass through the stroma with the ways in which cancers struggle to maintain fuel supply despite constraints

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