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In recent years, many studies have revealed that androgens can also regulate glucose and lipid metabolism upon binding to androgen receptors (AR) ( In addition to the gonadal organs, AR are also expressed in many major metabolic tissues, including the skeletal muscle, liver, pancreas, and brain, suggesting their important involvement in metabolism

Retrieved 2 October 2017

In their study, Lampl et al

As the mitochondria become damaged, they leak their contents into the cellular cytoplasm, which the immune system recognizes as a danger signal, further amplifying the inflammatory response in a vicious, self-perpetuating cycle

doi: 10.1007/s11916-011-0214-2