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Among the specific cancers examined, only lung cancer incidence was significantly higher in patients treated with ARBs

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In line with the UKB cohort data (ESM Table 9), vitamin B 12 deficiency was more prevalent in the AA genotype group treated with metformin vs GG (OR 2.17 [95% CI 1.80, 2.60]

In terms of safety, B12 is naturally occurring in the body and therefore (even in large doses) is relatively safe

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Running all three in a single protocol means you are addressing injury recovery, systemic healing, and collagen regeneration at the same time, rather than treating them as separate problems