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In brief, bilateral maxillary and mandibular second molars were both tied with 5-0 silk ligatures for 14 days to induce periodontitis

(1) Adolescence (1218 years): high sensitivity to high-sugar diets Although human studies investigating the gut microbiome in adolescents remain limited, the ongoing development of the gut-brain axis and the adolescent brain suggests that this population may be particularly susceptible to diet-induced depressive symptoms (320), The impact of high-sugar diets on metabolic and intestinal health In male C57BL/6J mice, consumption of a high-glucose diet (HGD) over a 12-week period induces hyperglycemia, glucose intolerance, dyslipidemia, and increased adipose deposition

Vagal Nerve Stimulation Decreases BloodBrain Barrier Disruption After Traumatic Brain Injury. Journal of Trauma and Acute Care Surgery 72: 15621566

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