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Disruptions in the intrinsic factor (IF) pathway, including impaired IF production due to autoimmune conditions (pernicious anemia), damage to the ileum from diseases like Crohns or celiac disease, or surgical resection of the ileum, can severely impair B12 absorption

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The result: severe water retention, numbness and tingling in the hands (carpal tunnel symptoms from excessive GH), facial flushing, and paradoxically reduced GH output as the pituitary downregulates its response

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