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Depending on the signals received in the plaque microenvironment, recruited monocytes can assume variety of macrophage identities including inflammatory macrophages, aortic intima-resident macrophages (Mac AIR ), and type I interferon-inducible cells

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Few clinical studies have evaluated its anticancer efficacy in humans, and mechanistic insights are largely confined to in vitro studies

Anethole dithiolethione increases glutathione in kidney by inhibiting -glutamyltranspeptidase: Biochemical interpretation and pharmacological consequences

Future trials should assess anti-VEGF injection burden, OCT and OCTA-based structural/perfusion outcomes, and circulating metabolic and exerkine biomarkers to define the clinical value of this integrative strategy (255, 259)

Once the desired results are achieved, a maintenance regimen can be followed, with a vial administered every two weeks or monthly, as needed