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It promotes resolution of inflammation by shifting macrophage activity from a pro-inflammatory (M1) phenotype toward a reparative (M2) phenotype, thereby effectively reducing fibrosis and promoting enhanced tissue regeneration [11, 23, 26, 50]
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Effects were seen at extremely low concentrations (10 -12 to 10 -9 M), but higher concentrations actually inhibited growth demonstrating a precise dose-response relationship
