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Code availability The software in this manuscript was available

Endocrine Connections, 6 (8), 647658

This radical has the potential to trigger lipid peroxidation (Equation 4) (Phaniendra et al., 2015)

Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer

COMT o-methylates catechol oestrogen metabolites and mediates their detoxification, and it is plausible that the activity of this enzyme is inhibited by the accumulation of the cysteine precursor homocysteine