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Description
This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

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415 VIT-2763 is under development as an oral medication targeting FPN for -thalassemia treatment
Funding This study was supported by the Key Laboratory of Infectious Diseases, CQMU (202004), the Grant from Science and Technology Bureau of Chengdu (No

Imipramine: Pharmacology of a Prototypical First-Generation Tricyclic Antidepressant (TCA)
Food Research, 4 (1), 1319
