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Functional studies have further demonstrated that MFAP2 knockdown suppresses tumor growth and is positively correlated with regulatory T cells (Tregs) and immune checkpoints such as CTLA4 and TIGIT, highlighting its potential as a prognostic biomarker and therapeutic target

Inter-individual variability driven by genetics, microbiome composition, and environmental exposures complicates interpretation, and current biomarkers require broader validation across diverse populations

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M.van DoornJ.CatsA.et al (2007)

10.5551/jat.65087 78 KawaguchiM.NakayamaA.AoyagiY.NakamuraT.ShimizuS.KawamuraY.et al (2021)

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