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While the causes leading to impaired wound healing are diverse, chronic wounds have many common features including excessive levels of pro-inflammatory immune cells and cytokines, high concentration of proteases, low levels of growth factors and a higher number of senescent cells 1,2

Accordingly, exploiting TMEassociated cues and cellular interactions has become a central direction for nextgeneration therapy

Relying on a single measurement standard could potentially affect our interpretation and summary of the outcomes

J Reprod Immunol 143:103248 Kiani K, Rudzitis-Auth J, Scheuer C, Movahedin M, Sadati Lamardi SN, Malekafzali Ardakani H, Becker V, Moini A, Aflatoonian R, Ostad SN, Menger MD, Laschke MW (2019) Calligonum comosum (Escanbil) extract exerts anti-angiogenic, anti-proliferative and anti-inflammatory effects on endometriotic lesions

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