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reported that glioma cells carrying the EGFRvIII mutation show an overactivation of mTOR, being less responsive to the anti-tumor effect of dacomitinib [319]

Phytochem Rev (2026)

88 Tiwari A, Surendra G, Meka S, et al

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6.3 Mechanistic understanding and complex interactions Although substantial progress has been found in recognizing the core pathways by which exercise may exert therapeutic effectsnamely through the regulation of oxidative stress and HPA axis functionour insight of the complicated relationship between these mechanisms continues to be incomplete