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Didier, M.F

In people of European descent, a much smaller but still significant fraction of the population (up to ~10-15%) carry the ABCG2 Q141K allele that causes renal urate transport functional impairment via ABCG2 dysfunction

These markers include executionary caspases 9 and 3, which are activated to cleaved form, holding effector activity to downstream proteins, such as activation of PARP-1 (Poly[ADP-ribose] polymerase 1), whose downstream cleavage is linked to an increase in DNA fragmentation in the nucleus, triggering apoptosis in cells [133,136,137,138]

3, e174 (2005)

The Seahorse buffer for cells cultured in glucose-deprived medium consisted of glucose-free DMEM, phenol red, 2 mM sodium pyruvate, and 2 mM glutamine

16 References Rajman, L., Chwalek, K., & Sinclair, D