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Red Blood Cell Formation : Vitamin B12 is needed for red blood cell production
doi: 10.1200/JCO.2000.18.3.562 20 LiuXMengQHYeYHildebrandtMATGuJWuX
Stadtman ER (2004) Role of oxidant species in aging

Renal impairment was thought to be caused by the precipitation of MTX and its metabolites in the renal tubules
These effects occur in a minority of users and rarely require stopping

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