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Chuan Huang Fang-II, composed of Rhizoma Chuanxiong and Rhubarb, has the effects of detoxifying and resolving stasis

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We further conducted a preliminary toxicity assessment of A80 in BALB/c mice and revealed that A80.2HCl showed no significant toxicity, as evidenced by the absence of adverse effects on body weight, liver and kidney function or other major organs (Supplementary Fig

Several preclinical and clinical studies have demonstrated that CSF1R inhibitors, including small-molecule tyrosine kinase inhibitors (e.g., PLX3397, GW2580, and Ki20227) and monoclonal antibodies targeting CSF1R or its ligand CSF1, can effectively deplete or reprogram TAMs, thereby improving tumor immune contexture and enhancing the efficacy of ICIs (161)

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We are currently amid an evolving revolution in obesity pharmacotherapy, with increasingly efficacious anti-obesity medicines (AOMs), incorporating uni-, bi- and trimolecular incretin receptor agonists [8, 9]