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Antioxid Redox Signal, 2017

Why glutathione alone is not enough: glutathione administered without vitamin C is rapidly oxidised back to GSSG

In the case of glutathione, the liposomes keep it in its reduced, or biologically active state

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introduced Zr into a manganese porphyrin-based MOF (Mn-MOF) to construct a biocompatible nanosensitizer along with the capacity of GSH exhaustion-enhanced ferroptosis (Figure 5F) (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis

doi: 10.1093/AOB/MCM052 126 MunnsR