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Furthermore, a newly synthesized compound targeting Cys174 at the DFG-1 position in TAK1 is considered a type II inhibitor (97)

While numerous compounds have demonstrated efficacy in vitro and in murine models, no phase I or II trials directly targeting NRF2 have been conducted in HCC patients, raising concerns about their applicability in clinical practice

Taking glutathione in orally will not do it its bioavailability is too low

[DOI] [PubMed] [Google Scholar] Dringen, R

doi: 10.1158/1535-7163.MCT-06-0053

As clinoptilolite particles are negatively-charged polyanions, they might also target cancer cells and induce additional oxidative stress upon entrance into the cytoplasm through hydrogen peroxide activation, increased production of ROS and its consequent depletion within the cell