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In individuals at risk of developing AD, amyloidopathy and oxidative stress can interact to increase the burden of NMDA receptor dysfunction

SPIs clinical data from two completed multi-center, randomized, placebo-controlled studies (Phase 1b and Phase 2b trials) showed that oral delivery of SPI-1005 for 21 or 28 days improved sensorineural hearing loss and tinnitus in patients affected by MD
10.1074/jbc.M204547200 23 HalabyD

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( TABLE 3 Antioxidant-functionalized biomaterials and redox-responsive delivery platforms for tendon regeneration

Shimada, K., Hayano, M., Pagano, N
