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Treatment effect appears to be clinically evident starting from one to three months after treatment completion, with a subsequent progressive decrease of the achieved EF benefit over time, although some effects could be still detected up to five years after treatment [490,492,498]

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doi: 10.1016/s0899-9007(99)00266-x

Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

38 Absent dose-limiting adverse effects, ALCAR, and ALA were increased to 1000 mg twice daily and 600 mg twice daily, respectively, at week 1 and to 1000 and 600 mg 3 times daily, respectively, at week 2