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M1 macrophages produce high levels of proinflammatory cytokines and upregulate the expression of the surface markers CD80 and CD86 [61], whereas M2 macrophages express anti-inflammatory markers and mediators, including the mannose receptors CD206 and CD163 [62]

Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells

In PhytochemicalsBiosynthesis, Function and Application: Volume 44 Springer, pp

The progression of the disease to a later stage has been shown to cause diffuse brain damage, known as septic encephalopathy (SE)

It also decreased TNF-, IL-6 in bronchoalveolar lavage fluid, and myeloperoxidase activity in lung extracts

In Step 1, the patient takes a SABA and a low-dose ICS together for symptom relief when symptoms occur