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CagriSema (the combination) was submitted for FDA approval in December 2025, but cagrilintide on its own is earlier in the process

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The BBB is constructed by specialized brain microvascular endothelial cells joined by tight junctions and supported by pericytes, astrocytic end-feet, and the basement membrane, collectively constituting the neurovascular unit (Kaya and Ahishali, 2021)