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SHBG is a protein produced in the liver that binds to testosterone, dihydrotestosterone (DHT), and estradiol (183)
The authors synthesized and designed ligand-drug conjugates with the melanocortin 1 receptor (MC1R) agonist melanotan-II (MT-II) to couple a cytotoxic drug, camptothecin with low cancer resistance (Figure 7)
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