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Mutagenicity and related end-points 7.7

and reduced nuclear levels of NF-B and the release of the pro-inflammatory cytokines IL-1 and IL-18, probably by preventing the ROS-mediated activation of the NF-B/NLRP3 inflammasome and stimulating the antioxidative Nrf2/HO-1 pathway [246]

doi: 10.3389/fphar.2021.750959

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Nutrients 10(11):1656

Together these modifications reduce IGFBP binding affinity by approximately 1,000-fold compared to native IGF-1 while preserving IGF-1 receptor (IGF1R) binding