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XJB-5-131 significantly inhibits the increase of tert-butyl hydroperoxide-induced ferroptosis-driving factors (PTGS2, TFR1, and ATF3) and the accumulation of ferroptosis markers (Fe 2+ , ROS, and lipid peroxide) in chondrocytes

If an active (reduced) glutathione stops a free radical, it itself is oxidised

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Alves-Fernandes D.K., Jasiulionis M.G

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(2021) 3:e200512

Additionally, the antiapoptotic protein Bcl-2 was found to be elevated in regions with increased IGF-1, while the proapoptotic protein Bax remained unchanged
