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Disposition of Dietary Polyphenols in Breast Cancer Patients Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin

Moreover, quercetin and its metabolites have been shown in vitro to exert weak to moderate inhibitory effects on key drug-metabolizing enzymes, including cytochrome P450 isoforms CYP3A4 and CYP2C19, as well as several major drug transporters (Mohos et al., 2020)

CD8 + T cells, activated by APCs via MHC class I molecules, differentiate into cytotoxic T lymphocytes (CTLs), which eliminate pathogen-infected or tumor cells through the release of perforin and granzymes [34, 35]