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Paraquat toxicity: proposed mechanism of action involving lipid peroxidation

This oxidation produces lipid peroxidation (LPO), which ultimately weaken the structural integrity of biological membranes and induce cell death (Yan et al

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Iodine deficiency in childhood affects the growth adversely

To lift the barrier, the cytosolic loops in SRD5A2 may undergo conformational changes during the reaction so that the cytosolic region can open up to expose the nucleotide-binding pocket to the cytosol before and after one reaction to allow NADP + /NADPH exchange, and thus efficient reaction turnover