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found that highly metastatic CRC cells primarily rely on glutamine-driven TCA cycle activity to sustain energy production, whereas low-metastatic cells tend to depend more on glycolysis [94]

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TP53 mutations can be detected in the early stages of 65% of secondary GBM multiforme (Rumpold et al., 2020), which provides a potential biomarker for early screening for extraneural metastases

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