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10.1101/gad.180885.111 117 ZuberB.UnwinN

PAR-1-knockout mice treated with a subpressor dose of Ang II for 4 weeks failed to cause vascular remodeling of the aorta but did induce cardiac hypertrophy, in contrast to the effect on wild-type mice, indicating that PAR-1 plays a significant role in vascular remodeling induced by Ang II without raising blood pressure

However, supplementation of the triple therapy with Bacillus subtilis and Enterococcus faecium possibly will restore the gastrointestinal microbiome (Hu et al
doi: 10.1016/j.molmed.2020.03.010
Surgery (2004) 136(3):54856