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This is consistent with a recent report that salvianolic acid A results in a dramatic activation of the Akt/mTOR signalling, followed by activation of the Nrf2/HO-1 axis in retinal pigment epithelia cells 60

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For instance, miR-145-5p has been implicated in RGC apoptosis via the PI3K/AKT signaling pathway, highlighting the potential of modulating microRNA expression as a neuroprotective strategy (115)

In addition, CBC attenuates lipopolysaccharide (LPS)-induced increases in nitric oxide levels in an in vitro model of colitis (Romano, et al., 2013) and reduces inflammation-induced GI motility (Izzo, et al., 2012)