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These proteins, which are generally encoded by a single gene, have been reclassified as two novel families of class I peroxidases (Lazzarotto et al

Oparin and the origin of life: a historical reassessment of the heterotrophic theory

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Mechanisms of oxidative stress may involve the formation of oxidants on the surface of SPM, the release of metals or organic components from particles and the initiation of an inflammatory response

J Gerontol A Biol Sci Med Sci 70(5):533544

Studies show that RNAi-induced GPX4 downregulation is sufficient to induce ferroptosis, while GPX4 overexpression in HT-1080 cells confers resistance to ferroptosis, and GPX4-deficient cells are more susceptible (Yang et al., 2014)