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The use of pharmacologic doses of VIC led to increased sensitivity to treatment

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However, higher doses can reduce the effects caused by oxidative stress and inflammation in COPD, demonstrating a positive impact on the rate of exacerbation [117]
Once in the nucleus, NF-B triggers the transcription of several inflammatory mediators, including additional cytokines, chemokines, and adhesion molecules, which spread inflammation (Rahman et al., 2018

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