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Within the Umbrella Labs program, Ibutamoren is treated as a research model in its own right, suitable for probing how long-acting GH-axis stimulation shapes body-composition proxies, tissue remodeling signatures, and related endpoints in bench workflows

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Nonetheless, the interpretation of these studies is complicated by the fact that these models are constitutive genetic deletions, and due to the lack of FA mobilization from adipocytes, these mice are completely reliant on glucose as a fuel source